Eccrine spiradenoma usually configures benign tumours of the skin located at the site of eccrine sweat glands. Malignant eccrine spiradenoma genetic and rare diseases. All structured data from the file and property namespaces is available under the creative commons cc0 license. The signs and symptoms of eccrine spiradenoma include. Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically characterized, clinically, as a solitary, deepseated dermal nodule of approximately one centimeter, occurring on the ventral surface of the body. An eccrine spiradenoma appears on mri as a subcutaneous cystic or solid mass, with low signal intensity on t1weighted images and intermediate to high signal intensity on t2weighted and stir images and enhancement on contrast imaging. The presentation is often that of a single nodule that may.
Eccrine glands play an important role in the regulation of body temperature. Apr 26, 2020 spiradenoma is a type of skin condition that causes benign tumors to develop and usually is associated with the sweat glands. This rare benign tumour should be considered for the differential diagnosis of solitary or. Eccrine spiradenoma es is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. Eccrine spiradenoma is a well recognized benign sweat gland tumour arising from the intradermal straight part of the duct of eccrine sweat glands. Age and sex distribution apocrine spiradenoma is an uncommon condition that is seen in the age range of 2060 years. Eccrine spiradenoma is an uncommon benign tumor of skin adwas approximately 1. The etiology of multiple es is unknown, but several theories have been suggested including a multipotent stem cell origin.
In most cases, only one nodule is present, although multiple lesions might appear in some cases. Contribution to eccrine spiradenoma jama dermatology. Jun 17, 2015 eccrine spiradenoma is an adnexal neoplasm that continues to be designated as a tumor with eccrine differentiation, however, it is currently considered an apocrine process. Siegel hj, saidalnaief n, long j, lopezben rr, klein m. Files are available under licenses specified on their description page. A case in which a young woman presented with a longstanding lesion of the forearm sustained after trauma is reported. Nov 14, 2011 malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. Eccrine spiradenoma definition of eccrine spiradenoma by. Here we report a case of eccrine spiradenoma of the breast skin in a 39yearold woman who presented with a breast nodule for 10 years. View abstract siegel hj, saidalnaief n, long j, lopezben rr, klein m. Apr 19, 2020 eccrine hidradenoma pdf eccrine hidradenoma is a rare benign cutaneous neoplasm, believed to arise from the distal excretory duct of the eccrine sweat glands 1.
Smears showed clusters of round to plasmacytoid cells with moderate to abundant cytoplasm embedded in a chondromyxoid ground substance. Cylindroma in this tumour the low power view shows discrete polygonal tumour islands. Current reports suggest that the tumor predominates in. This can cause secondary bacterial or fungal infections to develop superimposed infections some individuals may have concerns regarding their cosmetic appearance. Eccrine and apocrine naevi are rare malformations of the glandular component of an eccrine or apocrine gland.
Around 50 cases of eccrine spiradenoma have been reported in the literature. The disease usually appears as solitary gray, purple, pink, red, or blue nodules on the upper half of the body. A 44yearold male with a bluecolored, nodular tumor on the left knee. Malignant eccrine spiradenoma mes is an extremely rare sweat gland tumor that arises in a preexisting benign eccrine spiradenoma. Multiple eccrine spiradenomas in a zosteriform pattern. Painful eccrine spiradenoma containing nerve fibers.
Malignant eccrine spiradenoma with squamoid and chondroid. Aug 14, 2014 eccrine spiradenoma es is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. Benign eccrine spiradenoma is an adnexal tumor that occurs as either a solitary lesion or as multiple nodules. Brookespiegler syndrome no differences are seen between sporadic eccrine spiradenoma or those occurring in the context of this syndrome. Eccrine spiradenoma is an uncommon benign tumor of skin adnexa originating from eccrine glands, which was first described by kersting and. A case of eccrine spiradenoma of the left pinna is described. Es is a kind of neoplasm with distinct histological characteristics and nonspecific clinical manifestations. To the best of our knowledge, this is the first report regarding this site. This article is from journal of clinical medicine research, volume 1. Eccrine spiradenomas are uncommon, benign lesions, which are thought to originate from the eccrine sweat glands. It is crucial to take eccrine spiradenoma into consideration in superficial. Eccrine naevi produce either a mucinous discharge or a localized area of excessive sweating hyperhidrosis, which can occur spontaneously or following provoking factors such as heat. Although benign forms are not uncommon, malignant transformation of this tumour is rare. Eccrine spiradenoma is a benign sweat gland tumor occurring rarely in the hand.
Overall, the lesion was a firm, tender, welldefined, blue nodule with a smooth surface and obscure boundaries. Giant vascular eccrine spiradenoma gves is a variant of an eccrine spiradenoma. Giant vascular eccrine spiradenoma with unusual clinical. Eccrine spiradenoma is one of the rare adnexal tumors with eccrine differentiation. Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. Eccrine spiradenoma is a benign skin lesion and it may cause the following complications. Eccrine spiradenoma es is an uncommon tumor of eccrine sweat gland origin, occurring. The treatment was a surgical excision in safe margins. Eccrine spiradenoma is a benign tumor of the sweat gland that was first described by kersting and helwing in. Malignant eccrine spiradenoma archives of pathology. Eccrine carcinoma is an extremely rare malignancy of the skin with few well documented cases reported in the literature. Histochemistry of hidradenoma and eccrine spiradenoma.
Sweat gland lesions generally have variable apocrine or eccrine differentiation. They are common in young adults and are without a sex predilection. Like eccrine hidradenomas, the eccrine mixed tumor is grossly a well circumscribed and lobulated neoplasmwhich is usually enclosed by a distinct fibrous pseudocapsule. The latency period before transformation into malignant disease can range from 6 months to 70 years. Malignant eccrine spiradenoma on the lateral margin of nose. Since there are no typical signs or symptoms of this tumor, the diagnosis is often missed. A case of multiple eccrine spiradenoma occurring on. Pdf eccrine spiradenoma es is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its. Malignant eccrine spiradenoma on the lateral margin of. We present a malignant eccrine spiradenoma arising from a preexisting eccrine spiradenoma, which has an infrequent localization between lateral edge of nose and medial canthus.
Case report a 64yearold female patient was admitted to our department, with a 1. Eccrine spiradenoma is a benign adnexal neoplasm that has been historically designated as a tumor of eccrine differentiation, although current reconsideration indicates an apocrine process. Differential considerations of skin tumours with florid vascularisation. Multiple es is a rare variant of es and can present in a segmental, linear, blaschkoid, or zosteriform pattern. In our case, we present a 46 yearold female with a recurring exophytic tumor on the right lower extremity, without local extension. Contribution to eccrine spiradenoma jama dermatology jama. The prognosis for apocrine spiradenoma is excellent with suitable treatment. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. It is frequently found on the lower extremities, and it equally affects both sexes in the sixth and seventh decade. Cystic eccrine spiradenoma of the finger mimicking a.
Direct intracranial extension of malignant eccrine. It usually occurs as nodules on the skin, usually solitary sometimes many in numbers it is a slowgrowing tumor. Eccrine spiradenoma es typically presents as a solitary tender lesion. Eccrine spiradenoma is a benign sweat gland tumor, which can rarely undergo change to a malignant variety. Eccrine spiradenoma is a benign, painful tumor of the skin, which probably originates in the coil of the eccrine sweat glands and presents a characteristic clinical and pathological picture. Traditionally these lesions have been categorized under either the apocrine or eccrine groups, but significant overlaps do exist. Giant vascular eccrine spiradenoma gves is a rare variant of eccrine spiradenoma es, a tumor that develops from the sweat gland. A rare case of eccrine spiradenomatreatment and management. Eccrine spiradenoma es, as first described in 1956, is a rare, benign adnexal neoplasm that is able to present on any part of the body, with 15 of cases occurring in the extremities 4. Differential diagnosis of eccrine spiradenoma pathology. Although most cases are benign, occasional malignant transformation has been reported.
A metaanalysis of reported cases malignant eccrine spiradenoma is an aggressive sweat gland tumor with poorly understood behavior and no currently. Eccrine spiradenoma is now known as a benign sweat gland tumor that commonly affects young adults. All previously reported cases in english literature have been. Tumours with overlap features with eccrine spiradenoma can be seen. The exact cause of malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system immunosuppression may contribute to the. Eccrine spiradenoma with chondroid syringoma in blaschkoid. Eccrine spiradenoma es is a rare, benign adnexal neoplasm that has been historically designated as a tumor of eccrine differentiation. A case of multiple eccrine spiradenoma occurring on the scalp and mimicking multiple cylindroma. Clinic pathological study of an eccrine spiradenoma. The glands within a sweat gland naevus are increased in size and number from birth. These tumors typically develop only in adults, although it is possible for spiradenoma to affect anyone at any age. It starts as a rapidlygrowing bump on the head or abdomen, and may cause tenderness, redness, or an open wound. Eccrine spiradenoma is an adnexal neoplasm that continues to be designated as a tumor with eccrine differentiation, however, it is currently considered an apocrine process.
Spiradenoma is a type of skin condition that causes benign tumors to develop and usually is associated with the sweat glands. Carcinosarcoma ex eccrine spiradenoma of the vulva. We describe a case of malignant eccrine spiradenoma of a 41yearold male with a history of swelling over nape of neck f or 6yrs and recent onset of increase in size since 6 months. Gves is usually accompanied by bleeding andor ulceration, and of.
Gves is very rare and differs from the eccrine spiradenoma in its larger size clinically and marked vascularity histopathologically. Eccrine spiradenoma is rare in the fingers and has not been described as cystic when appearing in the hand. Abstractmalignant eccrine spiradenomas are exceedingly rare tumours. There is frequently a more prominent population of s100 positive dendritic cells while in eccrine spiradenoma there is a lymphocytic infiltrate. It differs from eccrine spiradenoma in its larger size and vascularity as well as propensity for bleeding and ulceration, which may cause a clinical misdiagnosis of vascular lesion or malignant tumor. Since there are no typical signs or symptoms of this tumor, the diagnosis. Eccrine spiradenoma es is an exceedingly rare sweatgland tumor, it usually presents as a solitary lesion and painful nodule. A 44yearold male with a bluecolored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically characterized, clinically, as a solitary, deepseated dermal nodule of approximately one centimeter, occurring on the ventral surface of the body 666 spiradenoma lesions are benign sudoriferous tumors, and have also been described as cystic epitheliomas of the sweat glands. However, in rare cases, some spiradenomas are known to transform into malignant lesions.
On histological examination a diagnosis of benign eccrine spiradenoma was made. The classical description of the eccrine spiradenoma by kersting and helwig 1 in 1956 defined this condition as a distinct clinicopathological entity. Eccrine spiradenoma is a tumor that may arise from sweat glands throughout the body. A case of eccrine spiradenoma of the thumb in a 34year old woman is reported. Sep 05, 2018 what are the possible complications of eccrine spiradenoma. The lesion presented as a nontender and multilobulated mass near the carpometacarpal joint. Benign eccrine spiradenoma of the thumb springerlink.
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